New antipurinergic drugs (antagonists) and propurinergic drugs (agonists) are now being synthesized and tested but few have yet completed Phase 3 clinical trials and been approved. "Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin." I dont ever recommend any products that I do not believe is 100% beneficial to my clients. All parts of the dandelion are edible. Thank you so much. Suramin is 20 or more times as powerful as remdesivir, which is the only currently approved anti-COVID-19 drug. i wish i could grasp what this means, as it states both suramin and plavix in one study. ! I was desperate, and I gave her one capsule, 150mg, of Sytrinol. This is meant only for research purposes. Suramin was shown to be safe and effective in three preclinical models of ASD9-11 and a small human clinical trial1 in peer-reviewed papers published between 2013-2017. It is the treatment of choice for sleeping sickness without central nervous system involvement. northwestern Africa and North America, is known . Cat's claw, hailing from a woody vine in the Amazon rainforest, is another herb with spectacular antiviral properties. (2020). A strange star shaped spice that has a really nice flavour. A vitamin B complex contains B6, B12, biotin, and folate, essential vitamins for the nervous system and can help with the formation of serotonin. It also has an, Trypan blue is so-called because it can kill trypanosomes, the parasites that cause sleeping sickness. He uses the root only. All rights reserved 2018 Mouthful Matters, ABN: 28 112 380 209, Suramin Contained In These Unusual Foods And Spices, DISCLAIMER: THIS WEBSITE DOES NOT PROVIDE MEDICAL ADVICE, Pine Needle Tea Easy To Make Massive Health Punch, Fennel essential oil (100% pure, therapeutic grade), Boost Your Immune System Naturally For Powerful Wicked Health, Chlorine Dioxide Powerful Against Spike Proteins In Your Body, https://www.bitchute.com/video/fRmqkRbuaKg6/, Baby Formula Ideas To Beat The Current Shortage, How To Use Fennel To Boost Your Immune System, Boost Your Immune System Daily For Energy And Cleansing, MMS A Powerful Purge To Overcome Parasites & Pathogens, Homemade Quinine / HCQ Easy Steps To Make Your Own. I do seek scientific confirmation of the safety and effectiveness of the herbs and remedies I use. readily accessible. Thats what Ive been told. Theres only one way to fight back and thats by joining my FREE newsletter. According to a comment on a doctor video Suramin inhibits Zika virus replication by interfering with virus attachment and release of infectious particles. Sartor, Oliver, Catherine A. McLellan, Charles E. Myers, and M. M. Borner. 100 Years of Suramin. antiviral activities [24], and most of these are generally of low toxicity, cheap and 2! [10], Rare side effects include hypersensitivity reactions causing difficulty breathing. This is handy to know if you cannot source a suitable pine tree in your area. Yes, those pesky little yellow flowers that seem to love gracing the best of lawns! "Suramin inhibition of growth factor receptor binding and mitogenicity in AKR2B cells." Naviaux Lab, 2023. et Zucc. A small, FDA-approved phase 1 clinical trial in 2017 tested suramin's effect on certain "core" autism symptoms in five boys, as compared with five boys given a placebo. and turpentine with sugar taken in a very small dose attracts viral loads to the sugar and the turpentine kills the viral load. Journal of clinical oncology 10, no. I am a mother. This information isn't meant to treat, cure or prevent any disease. bioRxiv preprint. [16], Suramin was first made by the chemists Oskar Dressel, Richard Kothe and Bernhard Heymann at Bayer AG laboratories in Elberfeld, after research on a series of urea-like compounds. They were ahead of their time back then. "Suramin rapidly alters cellular tyrosine phosphorylation in prostate cancer cell lines. Antiviral Res 143, 230-236. Research is already being hurriedly done in that direction in the hope that many lives can be saved and much severe illness avoided. Suramin (as mentioned by Dr Judy Mikovits, PhD) and Shikimic acid are both found within the needles of the common pine tree. Prunella vulgaris, widely distributed in China, Europe, 5! https://buff.ly/3KmTZZd, I am only on FB now by the grace of God. Proceedings of the National Academy of Sciences 83, no. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (3) This study also says suramin doesn't work well on p2x4. Researcher Dr Robert Naviaux of the San Diego School of Medicine gave suramin, a drug first developed in 1916, to 10 autistic boys between the ages of five and 14, and noted transformative results. Check with your physician if you . Many generations of locals strengthen their immunity with the help of natural teas from: Pine tree cones. The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes only. Naviaux, et al. Curcumin was the active ingredient in an intravenous infusion that killed the patient of a California-licensed naturopathic doctor. Suramin can be found in trees, plants and spices which may be growing even in your front lawn! I was excited by these findings too esp as I am also on the autism spectrum. Though it has been investigated for other diseases, including cancer, it is not approved for any therapeutic use in the United States. Homeopathic remedies have been praised by advocates for use against viruses and routine ailments. Janet Ossebaard is one from The Fall of the Cab/al series. These people invite evil spirits to come into them and tell the HS He must depart! ", 21. No I am not sure if they need to be heated for the Suramin to be released. Once all the needles have sunk to the bottom and the tea has cooled, pour through a strainer into Here he talks about suramin, which Dr Judy mentioned. "Suramin binds to plateletderived growth factor and inhibits its biological activity. I believe that most of the fake foods will be removed and people will learn how to eat food they were designed to eat. But of-course they would keep that completely secret and only use it for anyone of their own people who somehow was subjected to the j/a/b. More Powerful Immune System Boosters By Using Essential Oils! Naviaux, R.K. & Nguyen, K.V. Hosang, Markus. Ive seen some dandelions in a vegetable patch that were so big I could hardly believe how big they were. "Suramin in the treatment of AIDS: mechanism of action." I love the way she says that they wouldnt be injecting people unless they already knew what could be done to reverse it. ", 13. Suramin may cause serious side effects. [22], Suramin was studied as a possible treatment for prostate cancer in a clinical trial. 1. I wish I could. cryoEM studies reveal the binding of suramin to the RdRp catalytic site to prevent . [24][25][26][27], 8,8'-{Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]}di(1,3,5-naphthalenetrisulfonic acid), O=C(Nc1cc(ccc1C)C(=O)Nc3c2c(cc(cc2c(cc3)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)c8cccc(NC(=O)Nc7cc(C(=O)Nc6cc(C(=O)Nc5c4c(cc(cc4c(cc5)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)ccc6C)ccc7)c8, InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80), The references used may be made clearer with a different or consistent style of, World Health Organization's List of Essential Medicines, Learn how and when to remove this template message, "Suramin Injection Advanced Patient Information", "Micromedex Detailed Drug Information for the Consumer: Suramin (Injection route)", "Our Formulary Infectious Diseases Laboratories CDC", "Trypanosomiasis, human African (sleeping sickness)", "CDC Infectious Diseases Laboratory: Our Formulary", "Suramin Injection Advanced Patient Information - Drugs.com", "Synthesis and StructureActivity Relationships of Suramin-Derived P2Y, "Inhibition of receptor/G protein coupling by suramin analogues", "International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy", "International union of pharmacology. [15], The mechanism of action for suramin is unclear, but it is thought that parasites are able to selectively uptake suramin via receptor-mediated endocytosis of drug that is bound to low-density lipoproteins and, to a lesser extent, other serum proteins. Suramin. Thus, reduction in extracellular pH facilitates P2X2 and P2X2/3 receptors but inhibits P2X1, P2X3, P2X4 and P2X7 receptors (. The richest sources of life-giving suramin today are conifers growing in ecologically clean regions of Siberia. Suramin is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 M), and SirT5 (IC50=22 M). This also can be made up into a tea. I love the fact that you are speaking from what you yourself did excellent! The mark of the evil one is this: when people sell their souls to the devil by participating in ghastly human and ch/ild sa/crifice so they can obtain more power, finances and fame. C: Use with caution if benefits outweigh risks. S U R A M I N Suramin. (2014). National Center for Biotechnology Information. It's the first time we've been so close to having a drug that can potentially treat ASD symptoms. http://www.fedup.com.au, Dr Judy explicitly says that pine needle tea will NOT act as anecdote, in fact, it can be toxic and has similar properties to terpentine. (especially on purinergic signaling.) For a better experience, please enable JavaScript in your browser before proceeding. 2. HUGE! He also talks about some other VERY interesting information that you have to hear for yourself And of course, a health disclaimer. [2], The most frequent adverse reactions are nausea, vomiting, diarrhea, abdominal pain, and a feeling of general discomfort. A few Dandelion leaves in salads are good, and Fennel is great to eat. De Clercq, Erik. 10. 3 (1985): 265-273. Suramin works by causing the parasites to lose energy, which causes their death. Our research is aimed at discovering a completely new way to think about the cause and treatment of autism and dozens of other complex chronic disorders. Suramin is just the first in a new class of drugs that will be synthesized to help regulate purinergic signaling. Emerging microbes & infections 3, e62. Find a way that works for you so you can enjoy Suramin often throughout the day. I did feel better with better health after I drank it myself. National Institutes of Health. [2], Suramin was made at least as early as 1916. Suramin and trypan blue were detected using scheduled multiple reaction monitoring (MRM) with a dwell time of 30 ms in negative mode and retention time window of 7.5-8.5 min for suramin and 8.4 . In summary, a lowered pHe enhanced the activity of all agonists at P2X2 receptors but, with the exception of suramin, not antagonists. "Understanding the mechanism of the antimitogenic activity of suramin." Funny how uridine is a p2y2 agonist and so many people take it as a nootropic. I haven't seen night awake or silly giggling in the middle of the night since he started Kudzu. [6] In the United States it can be acquired from the Centers for Disease Control (CDC). Do you have any sense of whether the pine needles are higher than the others in suramin? 4 (1989): 499-508. [10] Suramin uncommonly affects the eyes causing watery eyes, swelling around the eyes, photophobia, and changes or loss of vision. Before you begin treatment with suramin, you and your doctor should . Dr. Naviaux no longer has any control over the next clinical studies or the priorities of different diseases for testing, although he is recommending ASD, ME/CFS, post-acute SARS-CoV-2 multi-system chronic fatigue syndrome, also called long-COVID, and post-treatment Lyme disease (PTLDS) as a few of the top candidates. I have been taking Sytrinol, 150 mg x 2 daily, for well over 6 months. ", 17.Kathir, Karuppanan Muthusamy, Thallapuranam Krishnaswamy S. Kumar, and Chin Yu. Food Shortage Coming Soon, County Returns $1.2M NIH Funds & Confirms Vaxx is a Bioweapon, Protect Babies Thru Adults From Dioxin Toxicity w/ Adequate Vit C, DETOX Dioxin Air & Soil Exposure w/ Broccoli Sprouts For Pennies, Natures Penicillin: For Pneumonia, Earache, Flu, Bronchitis & More. Too many people have stated its what they used with great results. 17 (1986): 6440-6444. Natural Protocol: This protocol may mitigate damage in those with "buyer's remorse" who've been injected with spike protein, graphene oxide, SM-102, and mRNA.The same protocol is very useful to protect those concerned with the spike protein transmission FROM those who've been injected.. 8. No Carter, not really. So there are a few different alternatives. Consult your own doctor. We loved pickled everything, sour the better. You can obtain enough from pine needle tea (pine, spruce, cedar and fir) . It loves the cold, the colder the better. Is there one specific product you would recommend? [4] It is unclear if it is safe when breastfeeding. A quick google search was not conclusive of whether Emodin inhibits the Pannexin 1 channel. Suramin (as mentioned by Dr Judy Mikovits, PhD) and Shikimic acid are both found within the needles of the common pine tree. The synthesis of suramin was an extension of Paul Ehrlich's pioneering work that showed that certain chemical dyes were concentrated in microbial parasites like the trypanosomes that cause African . Eastern White Pine Tree Needles: A Natural Source of Anti-Infective Compounds, Suramin is strongly inhibitory to the replication of the coronavirus spike protein. 17 (1987): 4694-4698. It has been recognized by prominent researchers for its abilities to lower cholesterol, protect against heart disease and even act as a preventive measure to avoid heart disease. The active ingredients in wormwood are toxic to most types of intestinal worms, including Giardia lamblia, a parasite responsible for giardiasis. Some Amish farms sell and ship this. Taken together, the results show that sgp130 may exert an anti-inflammatory effect on microglia and neurons by inhibiting IL-6 binding. Therefore only 5 boys received suramin by infusion. By facilitating the exit from the arrested mitochondrial progression needed to complete the healing cycle, recovery from chronic illnesses currently considered incurable may one day be possible. Hi Luke, These data indicate that sgp130 inhibits the LPS-induced IL-6 trans-signal and show IL-6 and its receptor are involved in maintaining sickness behavior. Regarding our own experiment with natural antipurinergic therapy, we've been trialing Kudzu for the past three weeks and the outcome has been pretty impressive. Based on this system, we have demonstrated that an aqueous extract from the Natural herb Prunella vulgaris (NhPV) displayed potent inhibitory effects on SCoV-2 SP (including SPG614 mutant) pseudotyped virus (SCoV-2-SP-PVs) mediated infections. [10] Other skin reactions include skin rash, swelling and stinging sensation. B: May be acceptable. Within minutes, behavior returned to normal. These are proving to be beneficial for people who have taken the jab, or those who come in contain with injected people and find they are experiencing bad symptoms. You must log in or register to reply here. [4], Suramin causes a fair number of side effects. Some batches of suramin contain impurities that are brown in color. Kudzu is POSSIBLY SAFE for most people when taken by mouth appropriately for up to 4 months or when injected intravenously (by IV) for up to 20 days. Thank you! Pure suramin is colorless when dissolved in water or saline as a 10% solution (100 mg/mL). Press question mark to learn the rest of the keyboard shortcuts. The Eastern White Pine (. I believe people are so caught up in their own little bubble that they have no idea of what is going on in the real world. Weve tried everything else. Suramin is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor. It is illegal to import suramin for human use without FDA approval. I love this Diana, thank you for sharing such good information. Trypan blue is derived from toluidine, that is, any of several isomeric bases, C14H16N2, derived from, The inhibitory effect of suramin from pine needles on the coronavirus spike protein, Zika and Chikungunya, Making pine needle tea is easy, and only requires fresh, young pine needles and hot water. "Suramin binds to plateletderived growth factor and inhibits its biological activity." "After the single dose, it was almost like a roadblock had been released," he said. The intracellular application of 100 mM ethanol did not affect the inhibition of current by 100 mM extracellular ethanol, suggesting that the alcohol inhibition of ATP-gated ion channel function involves the extracellular domain of the receptor. [2] Sore palms of the hands and soles of the feet, trouble seeing, fever, and abdominal pain may also occur. **For the Full Spike Protein Protocol (including NAC)to protect from transmission from the V and to help those who took the V,go here. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Oxymatrine is an immunomodulator that Dr Chia uses to treat enterovirus-associated ME/CFS. Controlled studies in pregnant women show no evidence of fetal risk. By the way, enterovirus can cause gastritis, as well as being linked to ME/CFS. So I encourage you to play with these things. please let me know if you try the two you mentioned at the start of this thread. Structural Basis For Repurposing A 100-Years-Old Drug Suramin For Treating COVID-19. Pine needle tea (obviously nothing poisonous as most pine nuts (from all pine cones ) are edible but some are poisonous she was just covering her ass so to speak ppl have been makin this kinda tea for ages it has high vitamin c and has been used against scurvy for Mariners for 1000s of years, Do you know if the dandylion, star anise, fennel or pine needles have to be in tea or heated to release the suramin? 7. Jaw dropping information on all food and the bodies response including learning difficulties. Happy researching. Wormwood is one of the most effective antiparasitic herbs in the world, and one of the best natural alternatives to Ivermectin. or Best Offer. Lots of amazing eating benefits in those ones. They do change our DNA in the sense that they take it back to how it was when we were a baby. Its a remedy used a very long time ago. Jason Shurka was interviewing Dr Judy Mikovits PhD., and he asked the leading question: Do you know of any way, to heal oneself from the injuries from the current injection? https://www.biorxiv.org/content/10.1101/2020.10.06.328336v1, 3. (2017) conducted a trial that studied the impact of a single dose of suramin in children with autism and compared their result to a group of children who received the placebo drug (Saline). Content may not be reproduced in any form. 9. For Candle Soap Incense Making Burners Scented Oils Bulk Lot. Being jabbed with strange substances and experiencing shedding from those individuals has become a reality in this world we live in. Unfortunately, the lawns that do not have any yellow flowers have often been treated with RoundUp which is about the very worst thing you can do. I have bought this before for myself just for good health. Coffey Jr, Robert J., Edward B. Leof, Gary D. Shipley, and Harold L. Moses. Also, Suramin not only blocks P2X7 but also the related Pannexin 1 channel. A polyanionic compound with an unknown mechanism of action. On September 5th, the FDA issued a proposed rule rejecting eleven substances nominated by the American Association of Naturopathic Physicians (AANP) and like-minded organizations for use in drug compounding, including curcumin and cesium chloride. The same protocol is very useful to protect those concerned with the spike protein transmission FROM those whove been injected. 11.Croci, R., Pezzullo, M., Tarantino, D., Milani, M., Tsay, S.-C., Sureshbabu, R., Tsai, Y.-J., Mastrangelo, E., Rohayem, J., Bolognesi, M., et al. especially valuable as potential new sources for rapid responses against the ongoing 4! . Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry. Journal of Biological Chemistry 295, no. [8][9] It is considered first-line treatment for Trypanosoma brucei rhodesiense, and second-line treatment for early-stage Trypanosoma brucei gambiense, where pentamidine is recommended as first line. Here are some certain foods that are known to contain Suramin and Shikimic Acid. @Jesse2233 but i think you are on the right track, as almost every medication is based on a "natural" supplement/herb. Suramin is a medication used to treat African sleeping sickness and river blindness. The first shoots used to be used as a spring tonic many years ago. I dont know but I do know that God will provide. When he had an ME attack (as he called them), he would boil a load of soya beans, which he claimed made him feel much better. You quoted Rheum Palmatum, but many other plants contain Emodin. 49 natural alternative to Ivermectin, due to its rapid degradation, low toxicity to mammals 16, and 50 effectiveness in controlling nematodes and ticks 17,18. I always come back to the analogy of a car. Structural Basis For Repurposing A 100-Years-Old Drug Suramin For Treating COVID-19. Unfortunately, the importance of ATP and related metabolites in regulating the symptoms of disease and the stages of the healing cycle has only recently been recognized. Kudzu is one although it is not as potent. However, even better than the medication known as Suramin, and one that does not produce all the adverse side effects that come with pharmaceutical drugs, perhaps Pine Needle Oil may serve as a natural silver bullet. Suramin is not extensively metabolized and about 80% is eliminated via the kidneys. This practical guide on natural alternatives has more than 200 supporting studies that represent the best of science-backed strategies for nutritional interventions in the prevention and treatment of COVID-19. Brown-colored suramin should not be used. Ha ha Jeff good point! Do you think that Rheum Palmatum is the richest plant? However, despite increased lipid solubility, alcohols with a molecular volume of > or = 46.1 ml/mol (1-butanol, 1-pentanol, trichloroethanol, and dichloroethanol) were without effect on the ATP-activated current. 16.Spigelman, Zachary, Amy Dowers, Susan Kennedy, Dennis DiSorbo, Michael O'Brien, Ronald Barr, and Ronald McCaffrey. Stinging nettle can be found online and at health food stores. No medical research confirms this yet, but people have been using suramin for autism and as a powerful antiviral. [3] In regions of the world where the disease is common suramin is provided for free by the World Health Organization (WHO). So we picked dandelions and split the stems washed them and put them in vinegarsometimes eating them before they were fully pickled. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. [5] It is on the World Health Organization's List of Essential Medicines. Journal of cellular physiology 132, no. Choose what fits your situation best. "Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes. But, I would research it to the uttermost if I were you! PloS one 9, e91765-e91765. It is a secondary agent in the treatment of Onchocerciasis (river blindness), but because of its toxicity, it is rarely used. The all natural form of suramin might be licorice root, NAC,vitamin C , green tea. What a super easy way to give my body Suramin on a regular basis. However, a small, randomized clinical trial conducted by Robert Naviaux, MD, PhD, professor of medicine, pediatrics and pathology, and colleagues at University of . [4] Common side effects include nausea, vomiting, diarrhea, headache, skin tingling, and weakness. Having said that, we can do a lot more about it than simply sitting around and waiting to see who is harmed or dies. Upon treatment with suramin, median individual glycosome volume increased from 0.0113 to 0.0127 m3 (p 0.037). According to credible, published research from scientists in Spain from La Quinta Columna, somebut not allinjections, appear to contain high levels of graphene oxide while some appear to be saline placebos. Suramin is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 M). Since a lowered pHe is also known to enhance agonist activity at P2X receptors on sensory neurones containing P2X2 transcripts, the sensitization by metabolic acidosis of native P2X receptors containing P2X2 subunits may have a significant effect on purinergic cell-to-cell signalling. XXIV. Ive just stumbled upon upon your site and discovered suramin can be obtained naturally. Fragrance Oil 4 oz. It would be interesting to know if I can get raw camel milk in Australia at least in the powdered form. "Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes." Intramuscular and subcutaneous administration could result in local tissue inflammation or necrosis[citation needed]. By accessing or using this website, you agree to abide by the Terms of Service, Full Disclaimer, Privacy Policy, Affiliate Disclosure, and Comment Policy. Suramin as medication is used to treat African sleeping sickness and river blindness. In this trial, 10 male children with ASD were grouped into five pairs, ages 5-14 years. https://www.bitchute.com/video/fRmqkRbuaKg6/ Suramin is used in the treatment of African sleeping sickness (African trypanosomiasis) and river blindness (onchocerciasis), infections caused by parasites. It is our hope that each success will lay the groundwork for more successes, and soon there will be a drug, device, and therapeutic Renaissance that will create dozens of new tools that doctors can use to regulate the cell danger response and help patients heal. Some of the other P2X7 and P2Y2 inhibiting compounds listed at the bottom of. Yes, it can certainly be found naturally.
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suramin natural alternative